abstract：:Exosomes are 30-150 nm extracellular vesicles mediating intercellular communication. Disease states can alter exosome composition affecting the message carried and thereby, its functional impact. The objective of this study was to identify proteins present in these vesicles in a mouse model of neuropathic pain induced...

journal_title：Journal of proteomics

authors： Jean-Toussaint R,Tian Y,Chaudhuri AD,Haughey NJ,Sacan A,Ajit SK

更新日期：2020-01-16 00:00:00

abstract：:Recently it was discovered that thioproline, an unnatural analog of proline, can arise in vivo from the reaction of cysteine and formaldehyde in cells under oxidative stress. Sequence-specific bioincorporation of thioproline into proteins was studied via shotgun proteomics of Escherichia coli (E. coli) cells. In a str...

journal_title：Journal of proteomics

authors： Liu J,Hao C,Wu L,Madej D,Chan W,Lam H

更新日期：2020-01-06 00:00:00

abstract：:Gluten, a group of proteins found in wheat, barley, and rye, is the trigger of celiac disease, an immune disorder that affects about 1% of people worldwide. The toxicity of partially hydrolyzed gluten (PHG) in fermented products is less well understood due to the significant analytical challenges in PHG characterizati...

journal_title：Journal of proteomics

authors： Cao W,Baumert JL,Downs ML

更新日期：2020-01-06 00:00:00

abstract：:Neuroblastoma, a cancer of the sympathetic nervous system, is the second most common pediatric cancer. A unique feature of neuroblastoma is remission in some patients due to spontaneous differentiation of metastatic tumors. 13-cis retinoic acid (13-cis RA) is currently used in the clinic to treat neuroblastoma due to ...

journal_title：Journal of proteomics

authors： Halakos EG,Connell AJ,Glazewski L,Wei S,Mason RW

更新日期：2019-10-30 00:00:00

abstract：:Protein malnutrition is a risk factor for developing visceral leishmaniasis. Because we previously demonstrated that protein malnutrition and infection with Leishmania infantum disrupts the splenic microarchitecture in BALB/c mice, alters T cell-subsets and increases splenic parasite load, we hypothesize that splenic ...

journal_title：Journal of proteomics

authors： Losada-Barragán M,Umaña-Pérez A,Rodriguez-Vega A,Cuervo-Escobar S,Azevedo R,Morgado FN,de Frias Carvalho V,Aquino P,Carvalho PC,Porrozzi R,Sánchez-Gómez M,Padron G,Cuervo P

更新日期：2019-09-30 00:00:00

abstract：:Prediabetes is a risk factor for the development of diabetes. Early diagnosis of prediabetes may prevent the onset and progression of diabetes and its associated complications. Therefore, this study aimed at the identification of novel markers for efficient prediction of prediabetes. In this pursuit, we have evaluated...

journal_title：Journal of proteomics

authors： Rathore R,Sonwane BP,Jagadeeshaprasad MG,Kahar S,Santhakumari B,Unnikrishnan AG,Kulkarni MJ

更新日期：2019-09-30 00:00:00

abstract：:Leishmaniasis is second most neglected disease after malaria and seems to be a worldwide concern because of increased drug resistance and non-availability of approved vaccine. The underlying molecular mechanism of drug resistance (Amp B) in Leishmania parasites still remains elusive. Herein, the present study investig...

journal_title：Journal of proteomics

authors： Garg G,Ali V,Singh K,Gupta P,Ganguly A,Sahasrabuddhe AA,Das P

更新日期：2019-09-15 00:00:00

abstract：:Sex-biased protein is thought to be able to drive the phenotypic differences in males and females in insects. In this study, 1385 and 1727 proteins were identified as differentially accumulated proteins (DAPs) by comparing the protein abundances at pupae stage with those at adult stage in ovary and testis of S.litura,...

journal_title：Journal of proteomics

authors： Sun R,Sun Z,Chen Y,Zhu F,Li Y,Zhong G,Yi X

更新日期：2019-08-30 00:00:00

abstract：:Heat shock protein 70s (Hsp70s) are a highly conserved class of molecular chaperones that fold a large proportion of the proteome. Nematostella vectensis (Nv) is an estuarine sea anemone that has emerged as a model species to characterize molecular responses to physiological stressors due to its exposure to diverse, e...

journal_title：Journal of proteomics

authors： Knighton LE,Nitika,Waller SJ,Strom O,Wolfgeher D,Reitzel AM,Truman AW

更新日期：2019-08-30 00:00:00

abstract：:Bovine and human respiratory syncytial viruses (BRSV, HRSV) are primary causes of pneumonia in calves and children respectively, with vaccination offering protection via antibody and cellular immune responses. However, with no vaccines currently licensed for human use, evaluation of local responses to BRSV vaccination...

journal_title：Journal of proteomics

authors： Gray D,Ellis JA,Gow SP,Lacoste SR,Allan GM,Mooney MH

更新日期：2019-07-30 00:00:00

abstract：:Several proteomics studies have been conducted to identify new cerebrospinal fluid (CSF) biomarkers in Multiple Sclerosis (MuS). However, the complexity of CSF and its invasive collection, limits its use. Therefore, the goal of biomarker research in MuS is to identify novel distinctive targets in CSF or in easily acce...

journal_title：Journal of proteomics

authors： Pieragostino D,Lanuti P,Cicalini I,Cufaro MC,Ciccocioppo F,Ronci M,Simeone P,Onofrj M,van der Pol E,Fontana A,Marchisio M,Del Boccio P

更新日期：2019-07-30 00:00:00

abstract：:Much attention has been paid to the broodiness of the Muscovy duck, but the molecular mechanism of broodiness remains largely unknown. In this study, the ovary tissues of Muscovy ducks during the broody and laying periods were used to investigate differentially expressed proteins (DEPs) by the iTRAQ-based proteomics a...

journal_title：Journal of proteomics

authors： Wu X,Pan X,Cao S,Xu F,Lan L,Zhang Y,Lian S,Yan M,Li A

更新日期：2019-07-30 00:00:00

abstract：:We present a new module integrated into the widely adopted PatternLab for proteomics to enable analysis of isotope-labeled peptides produced using dimethyl or SILAC. The accurate quantitation of proteins lies within the heart of proteomics; dimethylation has shown to be reliable, inexpensive, and applicable to any sam...

journal_title：Journal of proteomics

authors： Santos MDM,Lima DB,Silva ARF,Kurt LU,Clasen MA,Pinto AFM,Moresco JJ,Yates JR 3rd,Aquino P,Barbosa VC,Fischer JSG,Carvalho PC

更新日期：2019-06-30 00:00:00

abstract：:Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB) from progressive supranuclear palsy (PSP) and fron...

journal_title：Journal of proteomics

authors： Lachén-Montes M,González-Morales A,Schvartz D,Zelaya MV,Ausin K,Fernández-Irigoyen J,Sánchez JC,Santamaría E

更新日期：2019-06-15 00:00:00

abstract：:The Estuarine stonefish (Synanceia horrida) is recognised as one of the most venomous fish species in the world but the overall venom composition has yet to be investigated using in-depth transcriptomic and proteomic methods. To date, known venom components are restricted to a hyaluronidase and a large, pore-forming t...

journal_title：Journal of proteomics

authors： Ziegman R,Undheim EAB,Baillie G,Jones A,Alewood PF

更新日期：2019-06-15 00:00:00

abstract：:The partial proteome of Polybia paulista wasp venom was previously reported elsewhere using a gel-dependent approach and resulted in the identification of a limited number of venom toxins. Here, we reinvestigated the P. paulista venom using a gel-free shotgun proteomic approach; the highly dynamic range of this approa...

journal_title：Journal of proteomics

authors： de Souza CL,Dos Santos-Pinto JRA,Esteves FG,Perez-Riverol A,Fernandes LGR,de Lima Zollner R,Palma MS

更新日期：2019-05-30 00:00:00

abstract：:Proteins play an essential role in the biological processes associated with cancer. Their altered expression levels can deregulate critical cellular pathways and interactive networks. In this study, the mass spectrometry-based label-free quantification followed by functional annotation was performed to investigate the...

journal_title：Journal of proteomics

authors： Gomig THB,Cavalli IJ,Souza RLR,Vieira E,Lucena ACR,Batista M,Machado KC,Marchini FK,Marchi FA,Lima RS,de Andrade Urban C,Cavalli LR,Ribeiro EMSF

更新日期：2019-05-15 00:00:00

abstract：:Yersinia ruckeri is the aetiological agent of enteric redmouth (ERM) disease and is responsible for significant economic losses in farmed salmonids. Enteric redmouth disease is associated primarily with rainbow trout (Oncorhynchus mykiss, Walbaum) but its incidence in Atlantic salmon (Salmo salar) is increasing. Outer...

journal_title：Journal of proteomics

authors： Ormsby MJ,Grahame E,Burchmore R,Davies RL

更新日期：2019-05-15 00:00:00

abstract：:A combination between gel electrophoresis and smartphone technology is applied for quantifying proteins in a serum sample. Electrophoresis not only allows one to separate different proteins but also to build-up a calibration curve for those proteins. To expand its applicability, a smartphone allows one to capture a ge...

journal_title：Journal of proteomics

authors： de Jesus JR,Guimarães IC,Arruda MAZ

更新日期：2019-04-30 00:00:00

abstract：:Mass spectrometry is the technique of reference for the identification and quantification of proteins. Whereas ESI and MALDI ionization sources are inherently not quantitative being highly influenced by the chemical nature of the analyte and the matrix, ICP-MS uses a hard ionization source that destroys proteins into ...

journal_title：Journal of proteomics

authors： Calderón-Celis F,Encinar JR

更新日期：2019-04-30 00:00:00

abstract：:Jasmonates (JAs) are important phytohormones that regulate a wide range of plant processes, including growth, development and stress responses. Jasmonate ZIM-domain (JAZ) proteins are transcriptional repressors in JA signaling. Overexpression of JAZ7 was found to confer drought tolerance in Arabidopsis thaliana (A. th...

journal_title：Journal of proteomics

authors： Meng L,Zhang T,Geng S,Scott PB,Li H,Chen S

更新日期：2019-03-30 00:00:00

abstract：:Oxidized low-density lipoprotein (ox-LDL) can impair endothelial function and lead to the atherosclerosis development. Protein S-nitrosylation is sensitive to cellular redox state and acts as a crucial regulator and executor of nitric oxide (NO) signaling pathways. Aberrant S-nitrosylation contributes to the pathogene...

journal_title：Journal of proteomics

authors： Xu X,Qiu H,Shi F,Wang Z,Wang X,Jin L,Chi L,Zhang Q

更新日期：2019-03-20 00:00:00

abstract：:KDAC inhibitors (KDACi) overcome gefitinib primary resistance in non-small cell lung cancer (NSCLC) including mutant-KRAS lung adenocarcinoma. To identify which proteins are involved in the restoration of this sensitivity and to provide new therapeutic targets for mutant-KRAS lung adenocarcinoma, we performed an iTRAQ...

journal_title：Journal of proteomics

authors： Lehmann SG,Seve M,Vanwonterghem L,Michelland S,Cunin V,Coll JL,Hurbin A,Bourgoin-Voillard S

更新日期：2019-03-20 00:00:00

abstract：:Adenovirus Delta-24-RGD has shown a remarkable efficacy in a phase I clinical trial for glioblastoma. Delta-24-RGD induces autophagy in glioma cells, however, the molecular derangements associated with Delta-24-RGD infection remains poorly understood. Here, proteomics was applied to characterize the glioma metabolic d...

journal_title：Journal of proteomics

authors： González-Morales A,Zabaleta A,García-Moure M,Alonso MM,Fernández-Irigoyen J,Santamaría E

更新日期：2019-03-01 00:00:00

abstract：:Populations of small eukaryotic RNAs, in addition to relatively well recognized molecules such as miRNAs or siRNAs, also contain fragments derived from all classes of constitutively expressed non-coding RNAs. It has been recently demonstrated that the formation and accumulation of RNA fragments (RFs) is cell-/tissue-s...

journal_title：Journal of proteomics

authors： Jackowiak P,Lis A,Luczak M,Stolarek I,Figlerowicz M

更新日期：2019-02-20 00:00:00

abstract：:Despite research progresses, the chance to accurately predict the risk for diabetic nephropathy (DN) is still poor. So far, the first evidence of DN is micro-albuminuria, which is detected only 10-20 years after the onset of diabetes. Our goal is to develop new predictive tools of nephropathy starting from urine, whic...

journal_title：Journal of proteomics

authors： Magagnotti C,Zerbini G,Fermo I,Carletti RM,Bonfanti R,Vallone F,Andolfo A

更新日期：2019-02-20 00:00:00

abstract：:Soil fungistasis limits the effect of fungal agents designed to control plant-parasitic nematodes. Benzaldehyde is a fungistatic factor produced by soil microorganisms that can suppress conidial germination, but the molecular mechanism of this suppression is unknown. In this study, three conidial proteomes of Arthrobo...

journal_title：Journal of proteomics

authors： Liu T,Zou LJ,Tian DW,Can QY,Zhu ML,Mo MH,Zhang KQ

更新日期：2019-02-10 00:00:00

abstract：:The inflammatory response in chickens (Gallus Gallus domesticus) is an integral part of the bird's response to infection. Detailing proteomic changes occurring during infection would be beneficial to the poultry industry, offering opportunities for comparative pathophysiological analysis. The objective of this study w...

journal_title：Journal of proteomics

authors： Horvatić A,Guillemin N,Kaab H,McKeegan D,O'Reilly E,Bain M,Kuleš J,Eckersall PD

更新日期：2019-02-10 00:00:00

abstract：:The field of cancer immunotherapy has expanded rapidly in the past few years, with many new approaches entering the clinic for T cell mediated killing of tumors. Several of these clinical approaches involve the exploitation of a CD8 + T cell response against MHC I presented tumor antigens. Here, we describe the types ...

journal_title：Journal of proteomics

authors： Schmidt M,Lill JR

更新日期：2019-01-16 00:00:00

abstract：:A synopsis of in-cell NMR spectroscopic approaches to study interaction proteomics in prokaryotic and eukaryotic cells is presented. We describe the use of in-cell NMR spectroscopy to resolve high resolution protein structures, discuss methodologies for determining and analyzing high and low affinity protein-target st...

journal_title：Journal of proteomics

authors： Breindel L,Burz DS,Shekhtman A

更新日期：2019-01-16 00:00:00

abstract：:Peptide mass shifts were profiled using ultra-tolerant database search strategy for shotgun proteomics data sets of human glioblastoma cell lines demonstrating strong response to the type I interferon (IFNα-2b) treatment. The main objective of this profiling was revealing the cell response to IFN treatment at the leve...

journal_title：Journal of proteomics

authors： Tarasova IA,Chumakov PM,Moshkovskii SA,Gorshkov MV

更新日期：2019-01-16 00:00:00

abstract：:Increased life expectancy and broader restorative dental treatment alternatives for missing teeth have resulted in an increasing request of bone regeneration/augmentation procedures not only in healthy patients, but also in elderly and medically compromised ones. This is also combined with a growing demand for short i...

journal_title：Journal of proteomics

authors： Calciolari E,Donos N

更新日期：2018-09-30 00:00:00

abstract：:High-throughput technologies were used to identify venom gland toxin expression and to characterize the venom proteomes of two rear-fanged snakes, Ahaetulla prasina (Asian Green Vine Snake) and Borikenophis portoricensis (Puerto Rican Racer). Sixty-nine complete toxin-coding transcripts from 12 venom protein superfami...

journal_title：Journal of proteomics

authors： Modahl CM,Frietze S,Mackessy SP

更新日期：2018-09-15 00:00:00

abstract：:Glycoproteins play pivotal roles in a series of biological processes and their glycosylation patterns need to be structurally and functionally characterized. However, the lack of versatile methods to release N-glycans as functionalized forms has been undermining glycomics studies. Here a novel method is developed for ...

journal_title：Journal of proteomics

authors： Wang C,Qiang S,Jin W,Song X,Zhang Y,Huang L,Wang Z

更新日期：2018-09-15 00:00:00

abstract：:Atrazine (ATZ), the second most commonly used herbicide in the United States, is an endocrine disrupting chemical linked to cancer and a common drinking water contaminant. This study further investigates ATZ-related developmental toxicity by testing the following hypotheses in zebrafish: the effects of embryonic ATZ e...

journal_title：Journal of proteomics

authors： Horzmann KA,Reidenbach LS,Thanki DH,Winchester AE,Qualizza BA,Ryan GA,Egan KE,Hedrick VE,Sobreira TJP,Peterson SM,Weber GJ,Wirbisky-Hershberger SE,Sepúlveda MS,Freeman JL

更新日期：2018-08-30 00:00:00

abstract：:Deposition of calcium oxalate (CaOx) crystals in renal interstitium is one of the key factors that cause progressive inflammation in kidney stone disease. Macrophages are responsible for elimination of these crystals but their roles to worsen inflammatory process remain under-investigated. This study thus aimed to def...

journal_title：Journal of proteomics

authors： Singhto N,Thongboonkerd V

更新日期：2018-08-15 00:00:00

abstract：:Cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) are pulmonary genetic disorders associated with inflammation and heterogeneous progression of the lung disease. We hypothesized that respiratory exosomes, nanovesicles circulating in the respiratory tract, may be involved in the progression of inflammation-rela...

journal_title：Journal of proteomics

authors： Rollet-Cohen V,Bourderioux M,Lipecka J,Chhuon C,Jung VA,Mesbahi M,Nguyen-Khoa T,Guérin-Pfyffer S,Schmitt A,Edelman A,Sermet-Gaudelus I,Guerrera IC

更新日期：2018-08-15 00:00:00

abstract：:Protein lysine ubiquitination is a dynamic reversible post-translational modification that plays key roles in modulating different cellular processes. Porcine reproductive and respiratory syndrome virus (PRRSV) is a notorious pathogen, causing tremendous economic losses for the global swine industry. The possible invo...

journal_title：Journal of proteomics

authors： Zhang H,Fang L,Zhu X,Wang D,Xiao S

更新日期：2018-07-30 00:00:00

abstract：:FGF8 specifies early tooth development by directing the migration of the early tooth founder cells to the site of tooth emergence. To date the effect of the FGF8 in adult dental pulp has not been studied. We have assessed the regenerative potential of FGF8 by evaluating changes in the proteome landscape of dental pulp...

journal_title：Journal of proteomics

authors： Tsikandelova R,Mladenov P,Planchon S,Kalenderova S,Praskova M,Mihaylova Z,Stanimirov P,Mitev V,Renaut J,Ishkitiev N

更新日期：2018-07-15 00:00:00

abstract：:The underlying pathophysiological mechanisms involved in cerebral aneurysms rupture remain unclear. This study was performed to investigate the differentially expressed proteins between ruptured and unruptured aneurysms using quantitative proteomics. The aneurysmal walls of six ruptured aneurysms and six unruptured an...

journal_title：Journal of proteomics

authors： Jiang P,Wu J,Chen X,Ning B,Liu Q,Li Z,Li M,Yang F,Cao Y,Wang R,Wang S

更新日期：2018-06-30 00:00:00